China (Mainland)
Diamondsupplier 
L-(+)-ERGOTHIONEINE CAS NO.497-30-3
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/P,T/T
- Available Specifications:
- Product Details
Keywords
- 1H-Imidazole-4-ethanaminium,a-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-,hydroxide, inner salt, (S)-
- Ammonium,[1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl]trimethyl-, hydroxide, inner salt,L-(+)- (8CI)
- 1H-Imidazole-4-ethanaminium, a-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, innersalt, (S)-
Quick Details
- ProName: L-(+)-ERGOTHIONEINE
- CasNo: 497-30-3
- Molecular Formula: C9H15N3O2S
- Appearance: White off-white powder
- Application: Ergothioneine is a natural molecule
- DeliveryTime: 5-7 workdays after payment
- PackAge: 25kg/drum
- Port: Shanghai/Beijing
- ProductionCapacity: 100 Kilogram/Month
- Purity: 99%
- Storage: Store in -20°C
- Transportation: normal
- LimitNum: 1 Kilogram
- Related Substances: 99%
- Residue on Ignition: 0.1%
- Heavy Metal: 10ppm
- Valid Period: 2 years
Superiority
WLP Ingredient Inc was formerly known as Green Valley Biochemical, which was founded in Hong Kong in 2013 and WLPI was officially registered in 2019. In 2023, it reached a long-term strategic cooperation agreement with a local factory of plant extract. which already got HAHAL,KOSHER,ISO9001,ISO2200,HACCP,cGMP
Now it has developed into a comprehensive enterprise integrating R&D, production and sales. And after years of market accumulation and in response to customer needs, we have close cooperation in various fields and production such as human APIs, veterinary APIs, food additives, feed additives, vitamins, amino acids, etc
In the course of business, our company has always adhered to the principle of integrity first and won the praise of our customers. we hope that in the days to come,we can become your important partner and create a better future together
| Q1:Can i get some samples |
| A:Yes, we can provide 10-20 g sample for your testing, please contact us for more details. |
| Q2:What’s your MOQ |
| A:Our MOQ is 1kg. (Packed in aluminum foil bag) |
| Q3:How can I Buy |
| A:Proforma invoice will be sent first after confirmation of your purchase order,enclosed our bank information.Payment by T/T,L/C, or Paypal. |
| Q4:How can you confirm your quality If problem happens,how you treat with your client |
| A:You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and to get the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests. |
| Q5:How do you treat with quality complaint |
| All of products are strictly tested by our QC, and confirmed by QA. We do test for products to make sure all of them are qualified. In case any quality problem is confirmed to be caused by us,we will replace the goods or refund your payment immediately. |
| Q6:What's the delievry time |
| A:Usually 3 working days for small orders,and large orders need to be checked based on different products. |
Details
L-(+)-Ergothioneine is a naturally-occurring amino acid derived from histidine via hercynine. Ergothioneine is a stable antioxidant that scavenges and detoxifies free radicals and oxidants, increases intracellular thiol levels, controls nuclear factor-κB activation, and inhibits inflammatory gene expression. In addition, it inhibits the peroxynitrite-dependent nitration of nitrotyrosine, blocks oxidative DNA damage and cell death, and prevents the formation of xanthine and hypoxanthine. Ergothioneine is transported by the organic cation/carnitine transporter 1, which has been linked with autoimmune diseases, including rheumatoid arthritis and Crohn’s disease.
| Product Name: | L-(+)-Ergothioneine |
| CAS No. | 497-30-3 |
| Formula | C9H15N3O2S |
| Apperance: | powder |
| Color: | White |
|
Melting point |
275-277°C (dec.) |
|
Density |
1.2541 (rough estimate) |
|
Refractive index |
1.6740 (estimate) |
Ergothioneine is a natural amino acid derived from plants and can accumulate in animals, and studies have proved that it has the effect of antioxidants, it can effectively remove -OH, can chelate divalent iron ions and copper ions, prevent H2O2 from forming -OH under the action of iron ions or copper ions, and can also inhibit the oxidation of copper-dependent oxyhemoglobin and inhibit the peroxidation reaction that promotes arachidonic acid after myoglobin (or hemoglobin) is mixed with H2O2. Ergothioneine also strongly removes hypochlorous acid, thereby preventing the inactivation of A1-antiprotease. However, it does not inhibit the peroxidation of lipid particles in the presence of iron ions. Akanmu D et al. have shown that the presence of ergothioneine in the body at a certain concentration can act as an antioxidant.
Protective effect on cells
Ergothioneine is a powerful hypochlorous acid scavenger (HOCl), and while many compounds can react with hypochlorous acid, few can react as quickly as ergothioneine. A 1-antiprotease inhibitors (APIs), such as elastase, are particularly sensitive to hypochlorous acid, and physiological concentrations of ergothioneine are very effective in protecting the API against the inactivation caused by hypochlorous acid, since neutrophils are the main source of hypochlorous acid in the body, one of the functions of ergothioneine is to protect red blood cells from neutrophils from normal function or pathological sites of inflammation.
Anti-inflammatory effect
Peroxynitrite is an endogenous formation of the limited diffusion reaction of NO and superoxide, and is a strong oxidant involved in the pathophysiology of inflammation, such as ischemia-reperfusion injury, atherosclerosis, acute pneumonia, and sepsis. Ergothioneine inhibits peroxynitrosoanion-mediated oxidation of amino acids, such as tyrosine nitration, thus providing feasibility for the treatment of inflammation.
