Atenolol CAS NO.29122-68-7

Methyl testosterone is the in stock product in WLP Ingredient Inc.

WLP Ingredient Inc was formerly known as Green Valley Biochemical, which was founded in Hong Kong in 2013 and WLPI was officially registered in 2019. In 2023, it reached a long-term strategic cooperation agreement with a local factory of plant extract. which already got HAHAL,KOSHER,ISO9001,ISO2200,HACCP,cGMP

Now it has developed into a comprehensive enterprise integrating R&D, production and sales. And after years of market accumulation and in response to customer needs, we have close cooperation in various fields and production such as human APIs, veterinary APIs, food additives, feed additives, vitamins, amino acids, etc

In the course of business, our company has always adhered to the principle of integrity first and won the praise of our customers. we hope that in the days to come,we can become your important partner and create a better future together

Atenolol is a selective beta-1 adrenergic receptor antagonist.It is a long-acting, selective β1 adrenergic receptor blocker with a cardiac selective effect significantly stronger than metoprolol, and a weak inhibition of β2 receptors in vascular and bronchial smooth muscle.No endogenous sympathomimetic activity, no membrane stability, and no inhibition of myocardial contractility.This product can reduce the blood pressure of patients with hypertension and relieve the increase of blood pressure caused by exercise.At the same time, by reducing heart rate (8% ~ 34%) and the product of heart rate and blood pressure (9% ~ 40%), the severity and frequency of angina pectoris attacks can be reduced, and the oxygen consumption index of patients with acute myocardial infarction can be improved.Therefore, early application of this drug can reduce the area of myocardial infarction and prevent reinfarction, and long-term application can reduce the mortality of myocardial infarction or stroke.After oral administration, the absorption rate was 50% ~ 60%, and the peak time of blood drug was 2 ~ 4h.The bioavailability was about 60%, the plasma protein binding rate was about 46%, and the apparent volume of distribution was 0.8L/kg.Widely distributed in the body, a very small amount into the brain, can quickly cross the placenta, can accumulate in milk, but the concentration of blood drug in infants is very small.In adult patients with normal renal function, the elimination period was about 5-7h, and the total clearance rate was about 6L/h(100ml/min).The clearance period of children was shorter (4, 5h).About 46% of the absorbed drug is excreted in its full form in the urine.The decrease of clearance rate in patients with abnormal renal function is mainly related to glomerular filtration rate.